In Silico Identification of Small Molecules as New Cdc25 Inhibitors through the Correlation between Chemosensitivity and Protein Expression Pattern

In Silico Identification of Small Molecules as New Cdc25 Inhibitors through the Correlation between Chemosensitivity and Protein Expression Pattern

The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed ligand-structure-based approach and taking advant...

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Bibliographic Details
Main Authors: Antonino Lauria, Annamaria Martorana, Gabriele La Monica, Salvatore Mannino, Giuseppe Mannino, Daniele Peri, Carla Gentile
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
molecular docking
antiproliferative activity
cell cycle
DRUDIT
HepG2
Cdc25
Online Access:https://www.mdpi.com/1422-0067/22/7/3714

Internet

https://www.mdpi.com/1422-0067/22/7/3714

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