Novel Capsid-Specific Single-Domain Antibodies with Broad Foot-and-Mouth Disease Strain Recognition Reveal Differences in Antigenicity of Virions, Empty Capsids, and Virus-Like Particles

Novel Capsid-Specific Single-Domain Antibodies with Broad Foot-and-Mouth Disease Strain Recognition Reveal Differences in Antigenicity of Virions, Empty Capsids, and Virus-Like Particles

Foot-and-mouth disease (FMD) vaccine efficacy is mainly determined by the content of intact virions (146S) and empty capsids (75S). Both particles may dissociate into 12S subunits upon vaccine manufacturing, formulation, and storage, reducing vaccine potency. We report the isolation of capsid-specif...

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Bibliographic Details
Main Authors: Haozhou Li, Aldo Dekker, Shiqi Sun, Alison Burman, Jeroen Kortekaas, Michiel M. Harmsen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Vaccines
Subjects:
foot-and-mouth disease
virus-like particles
vaccine
nanobody
single-domain antibody
immunogenicity
Online Access:https://www.mdpi.com/2076-393X/9/6/620

Internet

https://www.mdpi.com/2076-393X/9/6/620

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