Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells

Multiple Environmental Signaling Pathways Control the Differentiation of RORγt-Expressing Regulatory T Cells

RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota. Recently, c-Maf emerged as a critical factor in the regulation of RORγt expression in Tregs. However, aside from c-Maf signaling, the...

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Bibliographic Details
Main Authors: Hind Hussein, Sébastien Denanglaire, Frédéric Van Gool, Abdulkader Azouz, Yousra Ajouaou, Hana El-Khatib, Guillaume Oldenhove, Oberdan Leo, Fabienne Andris
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
Treg subsets
transcription factors
RORγt
cell differentiation
signal transduction
c-Maf
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03007/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03007/full

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