Protein Binding of Lapatinib and Its N- and O-Dealkylated Metabolites Interrogated by Fluorescence, Ultrafast Spectroscopy and Molecular Dynamics Simulations

Protein Binding of Lapatinib and Its N- and O-Dealkylated Metabolites Interrogated by Fluorescence, Ultrafast Spectroscopy and Molecular Dynamics Simulations

Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to serum proteins and is readily biotransformed in humans, giving rise to several metab...

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Bibliographic Details
Main Authors: Inmaculada Andreu, Emilio Lence, Concepción González-Bello, Cristobalina Mayorga, M. Consuelo Cuquerella, Ignacio Vayá, Miguel A. Miranda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
femtosecond transient absorption
fluorescence
hypersensitivity reactions
lapatinib
metabolites
molecular dynamics simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.576495/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.576495/full

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