Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this review shows the multiplicity of its effects...

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Bibliographic Details
Main Authors:	Brücher Björn L.D.M., Jamall Ijaz S.
Format:	Article
Language:	English
Published:	EDP Sciences 2019-01-01
Series:	4 open
Subjects:	akt all alk-1 amp ampk apoptosis autophagy bax bcl-2 brdu breast cadherin cancer carcinogenesis cell transition chronic inflammation collagen collagenase colon ccc cox-1 cox-2 crp cxcl8 decorin diabetes dna egfr elastin elastase endometrium epidemiology epigenetics erk fibronectin fibrosis foxo3a genetics genomics grim-19 gtpase hcc her2/neu hif-1α hpv interleukin keratin keratinase kras; liver lox mapk mcp1 metastasis metformin microbiome microrna mmp mtor mtorc1 mutation nf-κb nlrp3 nrf-2 nsclc ovary pai-1 parp pathogenesis pck pepck pge2 ppa2 precancerous niche proteomics pyroptosis rna signaling snail somatic mutation theory stat3 t2d tgf timp1 vimentin virus
Online Access:	https://www.4open-sciences.org/articles/XXXXX/full_html/2019/01/fopen180009/fopen180009.html

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https://www.4open-sciences.org/articles/XXXXX/full_html/2019/01/fopen180009/fopen180009.html

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

Internet

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