NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology

NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology

In the striatum, specific N-methyl-d-aspartate receptor (NMDAR) subtypes are found in different neuronal cells. Spiny projection neurons (SPNs) are characterized by NMDARs expressing GluN2A and GluN2B subunits, while GluN2D is exclusively detected in striatal cholinergic interneurons (ChIs). In Park...

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Bibliographic Details
Main Authors: Manuela Mellone, Elisa Zianni, Jennifer Stanic, Federica Campanelli, Gioia Marino, Veronica Ghiglieri, Annalisa Longhi, Marie-Laure Thiolat, Qin Li, Paolo Calabresi, Erwan Bezard, Barbara Picconi, Monica Di Luca, Fabrizio Gardoni
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Neurobiology of Disease
Subjects:
NMDA receptor
GluN2D
Parkinson's disease
Levodopa-induced dyskinesia
Pharmacological target
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303000

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http://www.sciencedirect.com/science/article/pii/S0969996118303000

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