Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10.

Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10.

BACKGROUND: Matrix metalloproteinases (MMPs) may have pro and antifibrotic roles within the lungs, due to its ability to modulate collagen turnover and immune mediators. MMP-8 is a collagenase that also cleaves a number of cytokines and chemokines. METHODOLOGY AND PRINCIPAL FINDINGS: To evaluate its...

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Bibliographic Details
Main Authors: Emilio García-Prieto, Adrián González-López, Sandra Cabrera, Aurora Astudillo, Ana Gutiérrez-Fernández, Miriam Fanjul-Fernandez, Estefanía Batalla-Solís, Xose S Puente, Antonio Fueyo, Carlos López-Otín, Guillermo M Albaiceta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2951918?pdf=render

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http://europepmc.org/articles/PMC2951918?pdf=render

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