Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection.

Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection.

IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of MHC-II and other components relevant for antigen presentation, and that adjusts the composition and balance of complex cytokine responses. It is produced during immune responses by innate as well as adaptive...

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Main Authors: Katharina Borst, Sven Flindt, Patrick Blank, Pia-Katharina Larsen, Chintan Chhatbar, Jennifer Skerra, Julia Spanier, Christoph Hirche, Martin König, Tomas Alanentalo, Martin Hafner, Zoe Waibler, Klaus Pfeffer, Veronika Sexl, Gerd Sutter, Werner Müller, Theresa Graalmann, Ulrich Kalinke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008279

Internet

https://doi.org/10.1371/journal.ppat.1008279

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