Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target

Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. In each disease, tau self-assembles abnormally to form filaments that deposit...

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Bibliographic Details
Main Authors: Sebastian S. Oakley, Mahmoud B. Maina, Karen E. Marshall, Youssra K. Al-Hilaly, Charlie R. Harrington, Claude M. Wischik, Louise C. Serpell
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neurology
Subjects:
tau
tauopathies
Alzheimer's disease
tau aggregation inhibitors
in vitro models
self-assembly
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.590754/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2020.590754/full

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