Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques.

Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques.

IFN-I production is a characteristic of HIV/SIV primary infections. However, acute IFN-I plasma concentrations rapidly decline thereafter. Plasmacytoid dendritic cells (pDC) are key players in this production but primary infection is associated with decreased responsiveness of pDC to TLR 7 and 9 tri...

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Bibliographic Details
Main Authors: Timothée Bruel, Stéphanie Dupuy, Thomas Démoulins, Christine Rogez-Kreuz, Jacques Dutrieux, Aurélien Corneau, Antonio Cosma, Rémi Cheynier, Nathalie Dereuddre-Bosquet, Roger Le Grand, Bruno Vaslin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3907389?pdf=render

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http://europepmc.org/articles/PMC3907389?pdf=render

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