Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell lines

Melflufen, a peptide‐conjugated alkylator, is an efficient anti‐neo‐plastic drug in breast cancer cell lines

Abstract Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide‐conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells, where it is converted to the known alkylator melphalan...

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Bibliographic Details
Main Authors: Alexander Schepsky, Gunnhildur Asta Traustadottir, Jon Petur Joelsson, Sævar Ingthorsson, Jennifer Kricker, Jon Thor Bergthorsson, Arni Asbjarnarson, Thorkell Gudjonsson, Nina Nupponen, Ana Slipicevic, Fredrik Lehmann, Thorarinn Gudjonsson
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Cancer Medicine
Subjects:
alkylator
aminopeptidases
breast cancer
breast cancer cell lines
Melflufen
Online Access:https://doi.org/10.1002/cam4.3300

Internet

https://doi.org/10.1002/cam4.3300

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