Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands—A Role for CCL2

Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands—A Role for CCL2

Inducing T cell responses by therapeutic vaccination requires appropriate activation of antigen presenting cells (APCs). The use of virus-like particles (VLPs) containing Toll-like receptor (TLR) ligands has demonstrated remarkable potential in activating APCs and modulating the immune response both...

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Bibliographic Details
Main Authors: Ariane C. Gomes, Mona O. Mohsen, Julius E. Mueller, Fabiana M. S. Leoratti, Gustavo Cabral-Miranda, Martin F. Bachmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
VLP (virus-like particle)
CpG—oligonucleotides
dendritic cell (DC)
T cell—DC interactions
CCL2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01679/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01679/full

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