Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes

Stem cells derived from cartilage endplate (CEP) cells (CESCs) repair intervertebral disc (IVD) injury; however, the mechanism remains unclear. Here, we evaluated whether CESCs could transdifferentiate into nucleus pulposus cells (NPCs) via autocrine exosomes and subsequently inhibit IVD degeneratio...

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Bibliographic Details
Main Authors: Liwen Luo, Junfeng Gong, Hongyu Zhang, Jinghao Qin, Changqing Li, Junfeng Zhang, Yu Tang, Yang Zhang, Jian Chen, Yue Zhou, Zhiqiang Tian, Yao Liu, MingHan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cartilage endplate stem cells
differentiation
exosome
GATA binding protein 4
transforming growth factor-β1
intervertebral disk degeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.648201/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.648201/full

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