High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients

High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients

Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its rol...

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Bibliographic Details
Main Authors: Ting Wang, John Marken, Janice Chen, Van Bao Tran, Quan-Zhen Li, Mengtao Li, Karen Cerosaletti, Keith B. Elkon, Xiaofeng Zeng, Natalia V. Giltiay
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
TLR7
transitional B cells
SLE
autoantibodies
RNP
type I IFNs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01243/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01243/full

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