High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients
Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its rol...
Main Authors: | Ting Wang, John Marken, Janice Chen, Van Bao Tran, Quan-Zhen Li, Mengtao Li, Karen Cerosaletti, Keith B. Elkon, Xiaofeng Zeng, Natalia V. Giltiay |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-06-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01243/full |
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