Oocyte Cytoplasmic Gas6 and Heparan Sulfate (HS) are Required to Establish the Open Chromatin State in Nuclei During Remodeling and Reprogramming

Oocyte Cytoplasmic Gas6 and Heparan Sulfate (HS) are Required to Establish the Open Chromatin State in Nuclei During Remodeling and Reprogramming

Background/Aims: Previously, we found that silencing of growth arrest-specific gene 6 (Gas6) in oocytes impaired cytoplasmic maturation, resulting in failure of sperm chromatin decondensation (SCD) and pronuclear (PN) formation after fertilization. Thus, we conducted this study to determine the effe...

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Bibliographic Details
Main Authors: Kyeoung-Hwa Kim, Eun-Young Kim, Su-Yeon Lee, Jung-Jae Ko, Kyung-Ah Lee
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Gas6
Cytoplasmic maturation
Sperm chromatin decondensation
Heparan sulfate
Mitochondrial dysfunction
Glutathione
Open chromatin state
Online Access:https://www.karger.com/Article/FullText/486221

Internet

https://www.karger.com/Article/FullText/486221

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