Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

Development of broadly neutralizing antibodies (bnAb) against HIV-1 in infected adults is a multi-step process unachievable by current vaccine approaches. Here the authors reconstruct the ontogeny of an infant bnAb, which develops in fewer steps, and identify its unique features that may shorten the...

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Bibliographic Details
Main Authors: Cassandra A. Simonich, Laura Doepker, Duncan Ralph, James A. Williams, Amrit Dhar, Zak Yaffe, Lauren Gentles, Christopher T. Small, Brian Oliver, Vladimir Vigdorovich, Vidya Mangala Prasad, Ruth Nduati, D. Noah Sather, Kelly K. Lee, Frederick A. Matsen IV, Julie Overbaugh
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09481-7

Internet

https://doi.org/10.1038/s41467-019-09481-7

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