AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS

AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS

Oligodendrocyte dysfunction has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by progressive motor neuron loss. The failure of trophic support provided by oligodendrocytes is associated with a concomitant reduction in oligod...

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Bibliographic Details
Main Authors: Caroline Eykens, Elisabeth Rossaert, Sandra Duqué, Laura Rué, André Bento-Abreu, Nicole Hersmus, Annette Lenaerts, Axelle Kerstens, Nikky Corthout, Sebastian Munck, Philip Van Damme, Matthew G. Holt, Georg von Jonquires, Matthias Klugmann, Ludo Van Den Bosch, Wim Robberecht
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
amyotrophic lateral sclerosis
oligodendrocytes
monocarboxylate transporter 1
adeno-associated virus
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000061

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http://www.sciencedirect.com/science/article/pii/S2329050121000061

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