Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators.

Versatile assays for high throughput screening for activators or inhibitors of intracellular proteases and their cellular regulators.

BACKGROUND:Intracellular proteases constitute a class of promising drug discovery targets. Methods for high throughput screening against these targets are generally limited to in vitro biochemical assays that can suffer many technical limitations, as well as failing to capture the biological context...

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Main Authors: Hideki Hayashi, Michael Cuddy, Vincent Chih-Wen Shu, Kenneth W Yip, Charitha Madiraju, Paul Diaz, Toshifumi Matsuyama, Muneshige Kaibara, Kohtaro Taniyama, Stefan Vasile, Eduard Sergienko, John C Reed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2764853?pdf=render

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