Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line

Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line

Abstract Background Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the...

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Bibliographic Details
Main Authors: Tamara Viscarra, Kurt Buchegger, Ignacio Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Ili, Priscilla Brebi
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Biological Research
Subjects:
A2780 cell line
Carboplatin
Drug resistance
Wnt/β-catenin-signaling pathway
Integrin signaling pathway
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s40659-019-0220-0

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http://link.springer.com/article/10.1186/s40659-019-0220-0

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