Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells

Increased xCT and transsulfuration pathway has been associated with metabolic reprogramming of colorectal cancer. However, the correlation between these 2 events and the underlying molecular mechanism remains obscure. xCT expression was determined in tissue microarrays of colorectal cancer. RNA sequ...

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Bibliographic Details
Main Authors: Shanwen Chen, Dingfang Bu, Jing Zhu, Taohua Yue, Shihao Guo, Xin Wang, Yisheng Pan, Yucun Liu, Pengyuan Wang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
xCT
Hydrogen sulfide
OTUB1
Ferroptosis
Synthetic lethality
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000191

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http://www.sciencedirect.com/science/article/pii/S1476558621000191

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