IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae

IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae

IMP-type metallo-β-lactamases comprise one group of the “Big 5” carbapenemases. Here, a novel blaIMP-68 gene encoding IMP-68 (harboring a Ser262Gly point mutant of IMP-11) was discovered from meropenem-resistant but imipenem-susceptible Klebsiella pneumoniae TA6363. The Ser262Gly substitution was pr...

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Bibliographic Details
Main Authors: Hiroaki Kubota, Yasunori Suzuki, Rumi Okuno, Yumi Uchitani, Tsukasa Ariyoshi, Nobuyuki Takemura, Fuminori Mihara, Kazuhisa Mezaki, Norio Ohmagari, Mari Matsui, Satowa Suzuki, Tsuyoshi Sekizuka, Makoto Kuroda, Keiko Yokoyama, Kenji Sadamasu
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mSphere
Subjects:
enterobacteriaceae
klebsiella
antibiotic resistance
carbapenems
enzyme kinetics
genome analysis
plasmid-mediated resistance
Online Access:https://doi.org/10.1128/mSphere.00736-19

Internet

https://doi.org/10.1128/mSphere.00736-19

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