New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates

New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates

According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics. In addition, a fundamentally new strategy for the synthesis of compounds of this chemical class invol...

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Bibliographic Details
Main Authors: Liliana Azotla-Cruz, Irina V. Lijanova, Igor V. Ukrainets, Natalya V. Likhanova, Octavio Olivares-Xometl, Natalya L. Bereznyakova
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2017-01-01
Series:Scientia Pharmaceutica
Subjects:
alkyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate
alkylation
analgesic activity
2,1-benzothiazine
bioisosteric replacements
crystal structure
Online Access:http://www.mdpi.com/2218-0532/85/1/2

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http://www.mdpi.com/2218-0532/85/1/2

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