EspFu-Mediated Actin Assembly Enhances Enteropathogenic Escherichia coli Adherence and Activates Host Cell Inflammatory Signaling Pathways

EspFu-Mediated Actin Assembly Enhances Enteropathogenic Escherichia coli Adherence and Activates Host Cell Inflammatory Signaling Pathways

EPEC is among the leading causes of diarrheal disease worldwide. The colonization of the gut mucosa by EPEC results in actin pedestal formation at the site of bacterial attachment. These pedestals are referred to as attaching and effacing (AE) lesions. Here, we exploit the different molecular mechan...

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Bibliographic Details
Main Authors: Fernando H. Martins, Ashwani Kumar, Cecilia M. Abe, Eneas Carvalho, Milton Nishiyama-Jr, Chao Xing, Vanessa Sperandio, Waldir P. Elias
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
enteropathogenic e. coli
espfu/tccp
tir phosphorylation
pedestal formation
inflammation
Online Access:https://doi.org/10.1128/mBio.00617-20

Internet

https://doi.org/10.1128/mBio.00617-20

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