Trapping a salt-dependent unfolding intermediate of the marginally stable protein Yfh1

Trapping a salt-dependent unfolding intermediate of the marginally stable protein Yfh1

Yfh1, the yeast ortholog of frataxin, is a protein of limited thermodynamic stability which undergoes cold denaturation at temperatures above the water freezing point. We have previously demonstrated that its stability is strongly dependent on ionic strength and that monovalent or divalent cations a...

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Bibliographic Details
Main Authors: Bartomeu eVilanova, Domenico eSanfelice, Gabriel eMartorell, Piero Andrea Temussi, Annalisa ePastore
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
thermodynamic stability
NMR
Cold denaturation
frataxin
metallo proteins
salt dependence
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00013/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00013/full

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