Recent insights into the genotype–phenotype relationship from massively parallel genetic assays

Abstract With the molecular revolution in Biology, a mechanistic understanding of the genotype–phenotype relationship became possible. Recently, advances in DNA synthesis and sequencing have enabled the development of deep mutational scanning assays, capable of scoring comprehensive libraries of gen...

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Bibliographic Details
Main Authors: Harry Kemble, Philippe Nghe, Olivier Tenaillon
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Evolutionary Applications
Subjects:
Online Access:https://doi.org/10.1111/eva.12846