Expression, purification and characterization of hepatitis B virus X protein BH3-like motif-linker-Bcl-xL fusion protein for structural studies

Expression, purification and characterization of hepatitis B virus X protein BH3-like motif-linker-Bcl-xL fusion protein for structural studies

Hepatitis B virus X protein (HBx) is a multifunctional protein that interacts directly with many host proteins. For example, HBx interacts with anti-apoptotic proteins, Bcl-2 and Bcl-xL, through its BH3-like motif, which leads to elevated cytosolic calcium levels, efficient viral DNA replication and...

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Bibliographic Details
Main Authors: Hideki Kusunoki, Toshiyuki Tanaka, Toshiyuki Kohno, Hirokazu Kimura, Kazuo Hosoda, Kaori Wakamatsu, Isao Hamaguchi
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
BH3-like motif
Bcl-xL
Fusion protein
HBx
Purification
Structural characterization
Online Access:http://www.sciencedirect.com/science/article/pii/S240558081630156X

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http://www.sciencedirect.com/science/article/pii/S240558081630156X

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