Analytical validation and chromosomal distribution of regions of homozygosity by oligonucleotide array comparative genomic hybridization from normal prenatal and postnatal case series

Analytical validation and chromosomal distribution of regions of homozygosity by oligonucleotide array comparative genomic hybridization from normal prenatal and postnatal case series

Abstract Background Regions of homozygosity (ROH) are continuous homozygous segments commonly seen in the human genome. The integration of single nucleotide polymorphism (SNP) probes into current array comparative genomic hybridization (aCGH) analysis has enabled the detection of the ROH. However, f...

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Bibliographic Details
Main Authors: Jiadi Wen, Kathleen Comerford, Zhiyong Xu, Weiqing Wu, Katherine Amato, Brittany Grommisch, Autumn DiAdamo, Fang Xu, Hongyan Chai, Peining Li
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Cytogenetics
Subjects:
Regions of homozygosity (ROH)
Single nucleotide polymorphism (SNP) calling
Array comparative genomic hybridization (aCGH)
Online Access:http://link.springer.com/article/10.1186/s13039-019-0424-6

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http://link.springer.com/article/10.1186/s13039-019-0424-6

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