Comparative study on beneficial effects of vitamins B and D in attenuating doxorubicin induced cardiotoxicity in rats: Emphasis on calcium homeostasis

Comparative study on beneficial effects of vitamins B and D in attenuating doxorubicin induced cardiotoxicity in rats: Emphasis on calcium homeostasis

The use of doxorubicin (DOX) to treat various tumors is limited by its cardiotoxicity. This study aimed to investigate and compare the cardioprotective effects of nicotinamide (NAM) and alfacalcidol (1α(OH)D3), against DOX-induced cardiotoxicity. Sprague Dawley male rats received DOX (5 mg/kg, i.p.)...

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Bibliographic Details
Main Authors: Heba H. Awad, Marwa O. El-Derany, Eman M. Mantawy, Haidy E. Michel, Mona M. El-Naa, Rania A. Salah El-Din, Amany I. El-Brairy, Ebtehal El-Demerdash
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Doxorubicin
Cardiotoxicity
Calcium
Nicotinamide
Vitamin D
Alfacalcidol
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004613

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http://www.sciencedirect.com/science/article/pii/S0753332221004613

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