New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria

New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria

Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three aminoquinol...

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Bibliographic Details
Main Authors: Opsenica Igor, Selaković Milica, Tot Mikloš, Verbić Tatjana, Srbljanović Jelena, Štajner Tijana, Đurković-Đaković Olgica, Šolaja Bogdan
Format: Article
Language:English
Published: Serbian Chemical Society 2021-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
quinoline
bromobenzyl derivatives
antimalarials
β-hematin inhibitory activity
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392100005O.pdf

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http://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392100005O.pdf

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