Kinetics of inclusion body formation and its correlation with the characteristics of protein aggregates in Escherichia coli.

The objective of the research was to understand the structural determinants governing protein aggregation into inclusion bodies during expression of recombinant proteins in Escherichia coli. Recombinant human growth hormone (hGH) and asparaginase were expressed as inclusion bodies in E.coli and the...

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Bibliographic Details
Main Authors: Arun K Upadhyay, Aruna Murmu, Anupam Singh, Amulya K Panda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3315509?pdf=render