ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant behavior and survival of human SCLC cell lines. Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct ge...

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Bibliographic Details
Main Authors: Mark D. Borromeo, Trisha K. Savage, Rahul K. Kollipara, Min He, Alexander Augustyn, Jihan K. Osborne, Luc Girard, John D. Minna, Adi F. Gazdar, Melanie H. Cobb, Jane E. Johnson
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308506

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http://www.sciencedirect.com/science/article/pii/S2211124716308506

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