Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival remains unclear. Here the authors show that adipocytes emergent during ALL therapy aid the survival of ALL cells through a restrictive effect on the ALL proteome.

Bibliographic Details
Main Authors: Q. Heydt, C. Xintaropoulou, A. Clear, M. Austin, I. Pislariu, F. Miraki-Moud, P. Cutillas, K. Korfi, M. Calaminici, W. Cawthorn, K. Suchacki, A. Nagano, J. G. Gribben, M. Smith, J. D. Cavenagh, H. Oakervee, A. Castleton, D. Taussig, B. Peck, A. Wilczynska, L. McNaughton, D. Bonnet, F. Mardakheh, B. Patel
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25540-4

Internet

https://doi.org/10.1038/s41467-021-25540-4

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