Mouse and human genetic analyses associate kalirin with ventral striatal activation during impulsivity and with alcohol misuse

Mouse and human genetic analyses associate kalirin with ventral striatal activation during impulsivity and with alcohol misuse

Impulsivity is associated with a spectrum of psychiatric disorders including drug addiction. To investigate genetic associations with impulsivity and initiation of drug taking, we took a two-step approach. First, we identified genes whose expression level in prefrontal cortex, striatum and accumbens...

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Main Authors: Yolanda ePeña-Oliver, Fabiana M Carvalho, Sandra eSanchez-Roige, Erin B Quinlan, Tianye eJia, Tom eWalker-Tilley, Stuart L Rulten, Frances ePearl, Tobias eBanaschewski, Gareth eBarker, Arun eBokde, Christian eBüchel, Patricia eConrod, Herta eFlor, Jürgen eGallinat, Hugh eGaravan, Andreas eHeinz, Penny eGowland, Marie-Laure ePaillere, Tomas ePaus, Marcella eRietschel, Trevor W Robbins, Michael N Smolka, Gunter eSchumann, Dai N Stephens
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Genetics
Subjects:
Adolescent
fMRI
impulsivity
5-choice serial reaction time task
binge drinking
Monetary incentive delay
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00052/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00052/full

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