Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.

Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.

BACKGROUND: Newborn resuscitation with 100% oxygen is associated with oxidative-nitrative stresses and inflammation. The mechanisms are unclear. Hyaluronan (HA) is fragmented to low molecular weight (LMW) by oxidative-nitrative stresses and can promote inflammation. We examined the effects of 100% o...

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Bibliographic Details
Main Authors: Helene C D Østerholt, Ingrid Dannevig, Myra H Wyckoff, Jie Liao, Yucel Akgul, Mrithyunjay Ramgopal, Dan S Mija, Naeun Cheong, Christopher Longoria, Mala Mahendroo, Britt Nakstad, Ola D Saugstad, Rashmin C Savani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3372475?pdf=render

Internet

http://europepmc.org/articles/PMC3372475?pdf=render

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