Manipulating plant RNA-silencing pathways to improve the gene editing efficiency of CRISPR/Cas9 systems

Manipulating plant RNA-silencing pathways to improve the gene editing efficiency of CRISPR/Cas9 systems

Abstract Background The CRISPR/Cas9 system, composed of a single-guide RNA for target recognition and a Cas9 protein for DNA cleavage, has the potential to revolutionize agriculture as well as medicine. Even though extensive work has been done to improve the gene editing activity of CRISPR/Cas9, lit...

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Bibliographic Details
Main Authors: Yanfei Mao, Xiaoxuan Yang, Yiting Zhou, Zhengjing Zhang, Jose Ramon Botella, Jian-Kang Zhu
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Biology
Subjects:
CRISPR
Cas9
Genome editing
Viral suppressor
RNA silencing
TBSV p19
Online Access:http://link.springer.com/article/10.1186/s13059-018-1529-7

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http://link.springer.com/article/10.1186/s13059-018-1529-7

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