The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils

Cytoplasmic aggregation of the primarily nuclear TAR DNA-binding protein 43 (TDP-43) affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of frontotemporal lobar degeneration (FTLD) cases. The cellular prion protein, PrP<sup>C</sup>, has been recognized as a...

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Bibliographic Details
Main Authors: Carlo Scialò, Luigi Celauro, Marco Zattoni, Thanh Hoa Tran, Edoardo Bistaffa, Fabio Moda, Robert Kammerer, Emanuele Buratti, Giuseppe Legname
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
PrP<sup>C</sup>
TDP-43
fibrils
uptake
toxicity
Online Access:https://www.mdpi.com/1999-4915/13/8/1625

Internet

https://www.mdpi.com/1999-4915/13/8/1625

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