Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways.

Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways.

Lymphatic vessels play an important role in health and in disease. In this study, we evaluated the effects of GSK3-β inhibition on lung lymphatic endothelial cells in vitro. Pharmacological inhibition and silencing of GSK3-β resulted in increased lymphangiogenesis of lung lymphatic endothelial cells...

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Main Authors: Benjamin Stump, Shikshya Shrestha, Anthony M Lamattina, Pierce H Louis, Woohyun Cho, Mark A Perrella, Xingbin Ai, Ivan O Rosas, Florence F Wagner, Carmen Priolo, Jonathan Astin, Souheil El-Chemaly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213831

Internet

https://doi.org/10.1371/journal.pone.0213831

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