Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

Abstract Background Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain cells and can kill human glioma cells....

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Bibliographic Details
Main Authors: Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
Honokiol
Temozolomide
Glioma cells
Autophagy and apoptosis
Drug tolerance
Online Access:http://link.springer.com/article/10.1186/s12885-018-4267-z

Internet

http://link.springer.com/article/10.1186/s12885-018-4267-z

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