Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2

Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2

Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2 (LRRK2) regulating kinase activity, cellular localization, and ubiquitylation. Although binding between those proteins has been investigated, a comparative study of all human 14-3-3 isoforms interacting with...

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Bibliographic Details
Main Authors: Jascha T. Manschwetus, Maximilian Wallbott, Alexandra Fachinger, Claudia Obergruber, Sabine Pautz, Daniela Bertinetti, Sven H. Schmidt, Friedrich W. Herberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
LRRK2
14-3-3 proteins
isoform specificity
Parkinson’s disease
phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00302/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00302/full

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