Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells

Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells

<p>Abstract</p> <p>Background</p> <p>There are a growing number of reports on the sub-physiological temperature culturing of mammalian cells for increased recombinant protein yields. However, the effect varies and the reasons for the enhancement are not fully elucidated...

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Bibliographic Details
Main Authors: Sumitomo Yasuhiko, Higashitsuji Hiroaki, Higashitsuji Hisako, Liu Yu, Fujita Takanori, Sakurai Toshiharu, Candeias Marco M, Itoh Katsuhiko, Chiba Tsutomu, Fujita Jun
Format: Article
Language:English
Published: BMC 2012-10-01
Series:BMC Biotechnology
Subjects:
Cold shock protein
Stress response
Enhancer
Transcription factor
Recombinant protein
Online Access:http://www.biomedcentral.com/1472-6750/12/72

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http://www.biomedcentral.com/1472-6750/12/72

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