Regulation of RIG-I Activation by K63-Linked Polyubiquitination

Regulation of RIG-I Activation by K63-Linked Polyubiquitination

RIG-I is a pattern recognition receptor and recognizes cytoplasmic viral double-stranded RNA (dsRNA). Influenza A virus, hepatitis C virus, and several other pathogenic viruses are mainly recognized by RIG-I, resulting in the activation of the innate immune responses. The protein comprises N-termina...

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Bibliographic Details
Main Authors: Masaaki Okamoto, Takahisa Kouwaki, Yoshimi Fukushima, Hiroyuki Oshiumi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
RIG-I
ubiquitin
innate immunity
virus
signaling pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01942/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01942/full

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