Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction.

Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction.

Attaching/Effacing (A/E) pathogens including enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC) and the rodent equivalent Citrobacter rodentium are important causative agents of foodborne diseases. Upon infection, a myriad of virulence proteins (effectors) encoded by A/E path...

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Bibliographic Details
Main Authors: Andrea Hodgson, Eric M Wier, Kai Fu, Xin Sun, Hongbing Yu, Wenxin Zheng, Ho Pan Sham, Kaitlin Johnson, Scott Bailey, Bruce A Vallance, Fengyi Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004705

Internet

https://doi.org/10.1371/journal.ppat.1004705

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