Genome Evolution of Two Genetically Homogeneous Infectious Bursal Disease Virus Strains During Passages in vitro and ex vivo in the Presence of a Mutagenic Nucleoside Analog

Genome Evolution of Two Genetically Homogeneous Infectious Bursal Disease Virus Strains During Passages in vitro and ex vivo in the Presence of a Mutagenic Nucleoside Analog

The avibirnavirus infectious bursal disease virus (IBDV) is responsible for a highly contagious and sometimes lethal disease of chickens (Gallus gallus). IBDV genetic variation is well-described for both field and live-attenuated vaccine strains, however, the dynamics and selection pressures behind...

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Bibliographic Details
Main Authors: Liliana L. Cubas-Gaona, Alexandre Flageul, Céline Courtillon, Francois-Xavier Briand, Maud Contrant, Stephanie Bougeard, Pierrick Lucas, Hélène Quenault, Aurélie Leroux, Alassane Keita, Michel Amelot, Béatrice Grasland, Yannick Blanchard, Nicolas Eterradossi, Paul Alun Brown, Sébastien Mathieu Soubies
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Microbiology
Subjects:
IBDV
chicken B cells
evolution
7DMA
viral diversity
mutation frequency
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.678563/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.678563/full

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