Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12755 |