Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function.
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2016-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12755 |
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doaj-5c07a915d81b45039bdbbb7f2201b43f2021-05-11T11:19:08ZengNature Publishing GroupNature Communications2041-17232016-09-017111210.1038/ncomms12755Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporterChristian B. Billesbølle0Jonas S. Mortensen1Azmat Sohail2Solveig G. Schmidt3Lei Shi4Harald H. Sitte5Ulrik Gether6Claus J. Loland7Department of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenCenter for Physiology and Pharmacology, Institute of Pharmacology, Medical University ViennaDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse, NIHCenter for Physiology and Pharmacology, Institute of Pharmacology, Medical University ViennaDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenThe neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function.https://doi.org/10.1038/ncomms12755 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christian B. Billesbølle Jonas S. Mortensen Azmat Sohail Solveig G. Schmidt Lei Shi Harald H. Sitte Ulrik Gether Claus J. Loland |
spellingShingle |
Christian B. Billesbølle Jonas S. Mortensen Azmat Sohail Solveig G. Schmidt Lei Shi Harald H. Sitte Ulrik Gether Claus J. Loland Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter Nature Communications |
author_facet |
Christian B. Billesbølle Jonas S. Mortensen Azmat Sohail Solveig G. Schmidt Lei Shi Harald H. Sitte Ulrik Gether Claus J. Loland |
author_sort |
Christian B. Billesbølle |
title |
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter |
title_short |
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter |
title_full |
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter |
title_fullStr |
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter |
title_full_unstemmed |
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter |
title_sort |
transition metal ion fret uncovers k+ regulation of a neurotransmitter/sodium symporter |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-09-01 |
description |
The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function. |
url |
https://doi.org/10.1038/ncomms12755 |
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