Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function.

Bibliographic Details
Main Authors:	Christian B. Billesbølle, Jonas S. Mortensen, Azmat Sohail, Solveig G. Schmidt, Lei Shi, Harald H. Sitte, Ulrik Gether, Claus J. Loland
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12755

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spelling	doaj-5c07a915d81b45039bdbbb7f2201b43f2021-05-11T11:19:08ZengNature Publishing GroupNature Communications2041-17232016-09-017111210.1038/ncomms12755Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporterChristian B. Billesbølle0Jonas S. Mortensen1Azmat Sohail2Solveig G. Schmidt3Lei Shi4Harald H. Sitte5Ulrik Gether6Claus J. Loland7Department of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenCenter for Physiology and Pharmacology, Institute of Pharmacology, Medical University ViennaDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse, NIHCenter for Physiology and Pharmacology, Institute of Pharmacology, Medical University ViennaDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience and Pharmacology, Molecular Neuropharmacology and Genetics Laboratory, Faculty of Health and Medical Sciences, University of CopenhagenThe neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function.https://doi.org/10.1038/ncomms12755
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christian B. Billesbølle Jonas S. Mortensen Azmat Sohail Solveig G. Schmidt Lei Shi Harald H. Sitte Ulrik Gether Claus J. Loland
spellingShingle	Christian B. Billesbølle Jonas S. Mortensen Azmat Sohail Solveig G. Schmidt Lei Shi Harald H. Sitte Ulrik Gether Claus J. Loland Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter Nature Communications
author_facet	Christian B. Billesbølle Jonas S. Mortensen Azmat Sohail Solveig G. Schmidt Lei Shi Harald H. Sitte Ulrik Gether Claus J. Loland
author_sort	Christian B. Billesbølle
title	Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
title_short	Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
title_full	Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
title_fullStr	Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
title_full_unstemmed	Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
title_sort	transition metal ion fret uncovers k+ regulation of a neurotransmitter/sodium symporter
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-09-01
description	The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:sodium symporters function.
url	https://doi.org/10.1038/ncomms12755
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Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

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