IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts.

IFN-gamma mediates the rejection of haematopoietic stem cells in IFN-gammaR1-deficient hosts.

BACKGROUND: Interferon-gamma receptor 1 (IFN-gammaR1) deficiency is a life-threatening inherited disorder, conferring predisposition to mycobacterial diseases. Haematopoietic stem cell transplantation (HSCT) is the only curative treatment available, but is hampered by a very high rate of graft rejec...

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Bibliographic Details
Main Authors: Martin Rottman, Claire Soudais, Guillaume Vogt, Laurent Renia, Jean-François Emile, Hélène Decaluwe, Jean-Louis Gaillard, Jean-Laurent Casanova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC2214797

Internet

http://europepmc.org/articles/PMC2214797

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