The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

Biofilms formed byStaphylococcus aureus are poorly responsive to antibiotics. Here, Siala et al. show that an antifungal drug (caspofungin) enhances the activity of fluoroquinolone antibiotics against S. aureus biofilms by inhibiting an enzyme involved in synthesis of the biofilm matrix.

Bibliographic Details
Main Authors: Wafi Siala, Soňa Kucharíková, Annabel Braem, Jef Vleugels, Paul M Tulkens, Marie-Paule Mingeot-Leclercq, Patrick Van Dijck, Françoise Van Bambeke
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13286

Internet

https://doi.org/10.1038/ncomms13286

Similar Items