Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines

Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines

Recent studies have shown that sulforaphane (SFN) selectively inhibits the growth of ALDH+ breast cancer stem-like cells.Herein, a series of SFN analogues were synthesized and evaluated against breast cancer cell lines MCF-7 and SUM-159, and the leukemia stem cell-like cell line KG-1a. These SFN ana...

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Bibliographic Details
Main Authors: Ye-Hui Shi, Dong-Fang Dai, Jing Li, Yan-Wei Dong, Yin Jiang, Huan-Gong Li, Yuan Gao, Chuan-Ke Chong, Hui-Ying Li, Xiao-Qian Chu, Cheng Yang, Quan Zhang, Zhong-Sheng Tong, Cui-Gai Bai, Yue Chen
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
sulforaphane (SFN)
analogues
water soluble derivative
KG-1a
SUM-159
MCF-7
caspase-3
ALDH+
Online Access:http://www.mdpi.com/1420-3049/21/4/514

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http://www.mdpi.com/1420-3049/21/4/514

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