An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes

An Effective Concentration of 5-Aza-CdR to Induce Cell Death and Apoptosis in Human Pancreatic Cancer Cell Line through Reactivating RASSF1A and Up-Regulation of Bax Genes

Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present...

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Bibliographic Details
Main Authors: Mehdi Nikbakht Dastjerdi, Asaad Azarnezhad, Batool Hashemibeni, Mansour Salehi, Mohammad Kazemi, Zahra Babazadeh
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2018-09-01
Series:Iranian Journal of Medical Sciences
Subjects:
Decitabine
Pancreatic Neoplasms
DNA Modification Methylases
Methylation
Online Access:http://ijms.sums.ac.ir/index.php/IJMS/article/view/3610

Internet

http://ijms.sums.ac.ir/index.php/IJMS/article/view/3610

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